Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.
نویسندگان
چکیده
Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3?-exonucleases.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 44 شماره
صفحات -
تاریخ انتشار 2009